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青島農(nóng)業(yè)大學(xué)生殖科學(xué)研究院招收碩士調(diào)劑生啦——本人是實(shí)驗(yàn)室16級碩士，編輯此條信息招收碩士調(diào)劑生啦，此聯(lián)系方式為老師的聯(lián)系方式，要求專業(yè)方向與生物相關(guān)專業(yè)，總分在300分之上。調(diào)劑系統(tǒng)與3.17號晚上開啟，3.21面試，請有意向在生殖和發(fā)育相關(guān)方向發(fā)展的同學(xué)盡快聯(lián)系，聯(lián)系方式：程老師：13864805527，比個大心!!!歡迎歡迎——以下為沈偉教授簡介：-----

沈偉

性別:男

出生日期:1975-12-18

工作單位:動物科技學(xué)院生殖細(xì)胞生物學(xué)實(shí)驗(yàn)室

研究方向:生殖細(xì)胞發(fā)生與生殖干細(xì)胞

研究課題項(xiàng)目名稱來源位次本人角色經(jīng)費(fèi)開始時間結(jié)束時間

利用精子介導(dǎo)基因轉(zhuǎn)移技術(shù)制備轉(zhuǎn)基因動物的研究國家自然科學(xué)基金1主持82009-07-012012-09-09

優(yōu)質(zhì)高產(chǎn)轉(zhuǎn)基因肉羊新品系培育國家重大專項(xiàng)1主持4342009-07-012010-12-12

卵母細(xì)胞與卵泡形成的調(diào)控機(jī)制國家科技部1主持134

胚胎干細(xì)胞體外分化的卵母細(xì)胞減數(shù)分裂的分子調(diào)控國家基金委1主持17

動物卵母細(xì)胞發(fā)生的分子調(diào)控山東省杰青1主持50

Dazl和Stra8基因調(diào)節(jié)卵母細(xì)胞發(fā)生及減數(shù)分裂啟動的分子機(jī)制國家基金1主持60

卵原細(xì)胞減數(shù)分裂啟動及卵母細(xì)胞生長起始調(diào)節(jié)機(jī)制科技部9731主持300

發(fā)表論文及著作題目年份位次刊名索引

Exposure to Brefeldin A promotes initiation of meiosis in murine female germ cells 2014 1 Reproduction, Fertility and Developmen SCI

Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse 2014 1 Cell Cycle SCI

Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs newborn mouse primordial follicle assembly in vitro 2014 1 Environmental and Molecular Mutagenesis SCI

Ovarian cell-like cells from skin stem cells restored estradiol production and estrus cycling in ovariectomized mice 2014 7 Stem Cells Dev SCI

Reconstitution of gametogenesis in vitro: meiosis is the biggest obstacle 2014 4 Journal of Genetics and Genomics, SCI

Transgenerational inheritance of ovarian development deficiency induced by maternal diethylhexyl phthalate exposure 2014 1 Reproduction, Fertility and Development SCI

Insulin regulates primordial follicle assembly in vitro by affecting germ cell apoptosis and elevating estrogen 2014 1 Reproduction, Fertility and Development SCI

Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse 2013 1 Environmental and Molecular Mutagenesis SCI

Deleted in Azoospermia-Like (DAZL) enhances in vitro-derived porcine germ cell formation and meiosis 2013 2 Stem Cells Dev SCI

Recovery of functional oocytes from cultured premeiotic germ cells after kidney capsule transplantation 2013 1 Stem Cells Dev SCI

Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway 2012 1 Histochemistry and Cell Biology SCI

Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocyte 2012 1 Molcular Biology Report SCI

Midkine promotes proliferation of primordial germ cell by inhibiting the expression of the deleted in azoospermia-like gene 2012 1 Endocrionology SCI

A co-culture system with preantral follicular granulosa cells in vitro induces meiotic maturation of immature oocytes 2011 1 Histochemistry and Cell Biology SCI

Analysis of oocyte-like cells differentiated from porcine fetal skin-derived stem cell 2011 1 Stem Cell and Development, SCI

DNA methylation of germ cell-specific basic helix-loop-helix (HLH) of transcription factors, Sohlh2 and Figα, during germ cell development 2011 1 Mol Hum Reprod SCI

Murine folliculogenesis in vitro is stage-specifically regulated by insulin via the Akt signaling pathway 2010 1 Histochemistry and Cell Biology SCI

Effect of insulin on oogenesis from mouse fetal germ cells in a serum-free 3D culture system 2010 1 Reprod BioMed Online SCI

Maternal imprinting during mouse oocyte growth in vivo and in vitro 2009 1 Biochem Biophys Res Commun SCI

Pre-meiotic fetal mouse germ cells form typical oocyte-like cells but do not progress through meiosis in vitro 2009 1 Theriogenology SCI

Mature oocytes derived from purified mouse fetal germ cells 2008 5 Human Reproduction SCI

In vitro development of mouse fetal germ cells into mature oocytes 2007 1 Reproduction SCI

Targeting the exogenous htPAm gene on goat somatic cell beta- casein locus for transgenic goat production 2007 1 Molecular Reproduction and Development SCI

Serial nuclear transfer improves the developmental potential of mouse embryos cloned from oocytes matured in a protein-free medium 2007 5 Molecular Reproduction and Development SCI

Mouse oocytes derived from fetal germ cells are competent to support the development of embryos by in vitro fertilization 2006 1 Molecular Reproduction and Development SCI

Efficient and simple production of transgenic mice and rabbits using the new DMSO-sperm mediated exogenous DNA transfer method 2006 1 Molecular Reproduction and Development SCI

Human lactoferrin transgenic rabbits produced efficiently using DMSO-sperm mediated gene transfer. 2006 1 Reproduction, Fertility and Development SCI

Living offspring produced by mouse oocytes derived from premeiotic fetal germ cells 2006 1 Biology of Reproduction SCI

沈偉，博士，教授。1975年生，山東滕州市人。教育部新世紀(jì)優(yōu)秀人才，山東省自然科學(xué)杰出青年基金獲得者，動物生殖與種質(zhì)創(chuàng)新山東省高校重點(diǎn)實(shí)驗(yàn)室負(fù)責(zé)人和首席專家，山東省“動物遺傳育種與繁殖”重點(diǎn)學(xué)科學(xué)術(shù)帶頭人，山東省優(yōu)秀研究生導(dǎo)師、青島市優(yōu)秀教師，生殖生物學(xué)會理事，動物遺傳標(biāo)記學(xué)會理事，美國生殖生物學(xué)學(xué)會正式會員。Gene、PlosONE、Stem Cell Epigenetics等刊物編委，Development等30余種國際雜志審稿人。研究方向?yàn)樯�殖�?xì)胞發(fā)生與生殖干細(xì)胞，主要圍繞與動物繁殖潛能開發(fā)、人類生殖健康等相關(guān)問題，進(jìn)行生殖干細(xì)胞和原始生殖細(xì)胞(PGC)的增殖與分化、卵母細(xì)胞發(fā)生的細(xì)胞互作與分子調(diào)節(jié)機(jī)制、動物生物技術(shù)育種等方面的研究。

2004年7月獲得了西北農(nóng)林科技大學(xué)與軍事醫(yī)學(xué)科學(xué)院聯(lián)合培養(yǎng)博士學(xué)位，2006年6月北京大學(xué)細(xì)胞生物學(xué)博士后出站，2007年7月破格晉升為教授，2007年8月至2008年8月中國科技大學(xué)客座研究，2009年9月至2010年8月加拿大Guelph大學(xué)博士后。

近5年來，先后主持了國家重大科學(xué)研究計劃(973)“卵泡發(fā)育的分子調(diào)控”等項(xiàng)目的子課題4項(xiàng)，國家自然科學(xué)基金“胚胎干細(xì)胞體外分化的卵母細(xì)胞減數(shù)分裂的分子調(diào)控”等4項(xiàng)，國家轉(zhuǎn)基因生物新品種培育重點(diǎn)項(xiàng)目“優(yōu)質(zhì)高產(chǎn)轉(zhuǎn)基因肉羊新品系培育”2項(xiàng)，山東省自然科學(xué)杰出青年基金“動物卵母細(xì)胞發(fā)生的分子調(diào)控”1項(xiàng)，參加國家973項(xiàng)目、863重點(diǎn)項(xiàng)目、國家自然科學(xué)基金等課題10余項(xiàng)。

帶領(lǐng)的研究組建立了從減數(shù)分裂前的雌性生殖細(xì)胞向卵母細(xì)胞體外發(fā)生、發(fā)育的培養(yǎng)體系，使卵原細(xì)胞在體外順利完成了減數(shù)分裂的啟動，并成熟、受精后獲得發(fā)育的囊胚;利用該體系系統(tǒng)研究了卵母細(xì)胞發(fā)生的分子調(diào)節(jié)機(jī)制，以及印跡基因DNA甲基化建立和擦除的影響機(jī)制。建立了原始卵泡體外形成與發(fā)育的模型，并獲得了體外受精的囊胚;利用該模型，系統(tǒng)研究了卵泡形成與募集過程中PI3K/Akt信號通路的調(diào)節(jié)機(jī)制。近5年來，沈偉教授研究組在《Endocrinology》、《Cell Cycle》、《Stem Cell Dev》、《Histochem Cell Biol》、《Biol Reprod》、《Mol Hum Reprod》、《Reproduction》、《Biochem Biophys Res Commun》、《Reprod BioMed Online》、《Mol Reprod Dev》、《Reprod Fertil Dev》和《Theriogenology》等刊物上發(fā)表研究論文50余篇。已培養(yǎng)研究生22人，皆發(fā)表了SCI收錄論文，有研究生第一作者發(fā)表的論文累積影響因子達(dá)9.454，半數(shù)以上的研究生到了國內(nèi)外重點(diǎn)大學(xué)和研究機(jī)構(gòu)進(jìn)行繼續(xù)深造。目前在讀碩士研究生11人、博士研究生4人。

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