2006.10 - 2010.10: Postdoctoral fellow, Sars International Centre for Marine Molecular Biology, Bergen, Norway;
2001.7 - 2005.7: Ph.D., Institute of Oceanology, Chinese Academy of Sciences (IOCAS), Qingdao, China.
Research Interests
Our group is principally interested in uncovering cellular processes and the underlying mechanisms that support the biological tube formation. We use marine animal (Ciona) notochord and Drosophila tracheal system as models to understand the morphogenetic signaling network on polarized vesicle trafficking, cytoskeletal organization, membrane biogenesis and extracellular matrix dynamics during lumen formation and cell shape change.
Job and Contact
We are always looking for people with experience and interests in developmental biology, Cell biology or biophysics to join us. If you are interested in working with us as a graduate student, postdoc or visiting scientist, please contacts us for possible openings.
Laboratory for Molecular Mechanisms and Cellular Biophysics of Organogenesis
College of Marine Life Sciences, Ocean University of China
1. Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E*, Dong B*, Jiang D*. Assembly and positioning of actomyosin rings by contractility and planar cell polarity. eLife, 2015. 4: e09206. (*Corresponding authors).
Commentary in: Nir S. Gov, Saoirse S. McSharry, and Greg J. Beitel, Three-ring circus without a ringmaster: Self-organization of supracellular actin ring patterns during epithelial morphogenesis.PNAS, 2015 112 (28): 8521-8522.
3.董波。海洋模式動物海鞘及其脊索發育與調控。科學通報,2015,60: 1167-1179.
4. Denker E, Sehring I, Dong B, Audisso J, Mathiesen B, Jiang D. Regulation by a TGFβ-ROCK-actomyosin axis secures a non-linear lumen expansion that is essential for tubulogenesis.Development, 2015, 142: 1639-1650.
5. Dong B, Hayashi S. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134.
6. Dong B, Miao GX, Hayashi S. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014, 141(21): 4104-4109.
Selected as a highlight in this issue “Fat body shapes up the trachea”,
7. Dong B*, Hannezo E, Hayashi S*. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports,2014, 7(4): 941-950. (*Corresponding authors).
8. Sehring I‡, Dong B‡, Denker E, Deng W, Jiang D. An Equatorial Contractile Mechanism Drives Cell Elongation but not Cell Division. PLOS Biology, 2014, 12(2): e1001781. (‡Co-first authors)
Comment in: A real stretch: mechanisms behind cell elongation. [PLoS Biol. 2014]http://www.ncbi.nlm.nih.gov/pubmed/24503562
9. DongB, KakiharaK, Otani T, WadaH, Hayashi S. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications.2013, 4, 1358.
Selected as a Recommended Read by Faculty of 1000. http://f1000.com/9601956
11. Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D. Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology 2009, 330: 237-249.